Dr. Ishani Arora is devout, ethically minded, and responsible. Dr. Siddhant "Sid" Mathur is carefree, flirty, and focused on getting the job done. Unable to understand each other, the two start off disliking each other. As Ishani and Sid work together, a friendship sparks between them. Misunderstandings occasionally divide the two, but they find resolution. Slowly the two develop feelings for each other, and eventually confess their feelings. Meanwhile, Dr. Asha Kanwar gets pregnant with Dr. Aman Gehlot's child out of wedlock. Unable to handle the situation, Dr. Aman runs away. Sid fakes being married to Dr. Asha to protect her unborn child. Ishani is left heartbroken, but later learns the truth. Under Vardhan Makhija's instructions, Asha plots to keep Sid and Ishani separated, since Vardhan wants to use Sid to get revenge on Dr. Shashank Gupta. Ishani, with the help of Dr. Rahil Shekhar, investigates the matter and tries to warn Sid about Asha and her intentions. Initially Sid does not believe her but eventually learns the truth. A furious Sid exposes Asha in front of the staff of Sanjivani. Ishani is shot protecting Asha and her unborn child. She undergoes surgery but slips into a coma. Guilty, Asha accepts her misdeeds, backs out of Vardhan's plans and seeks forgiveness.
After A Few Days
Ishani recovers. Dr. Shashank dies in a car accident, leaving the Sanjivani staff distraught. Sid learns that Shashank was his father. Ishani and Sid expose Vardhan, and he is arrested. Ishani and Sid decide to marry, but Sid is blackmailed by Ishani's relatives to stay away from her. When Sid does not arrive at the mandapa, Ishani is left devastated. Sanjivani Hospital is shut down.
3 years later
Navratan Singh buys Sanjivani Hospital and reopens it. Ishani is dejected, but Navratan motivates Ishani to give life a second chance. Ishani sees Sid in a comatose condition, reminding her of her past and bringing back her feelings of sadness. Sid regains his consciousness but has partially lost his memory, but Ishani operates on him and he recalls everything. Sid exposes Ishani's relatives and reveals why he had not arrived to marry her and Ishani is left shocked. Navratan marries Ishani and Sid and the show ends.
