Calm and practical, Dr. Rohit Sippy is a heart surgeon, swearing by logic and science. Chirpy and vivacious, Sonakshi Rastogi is a television actress, living in a world of fiction and dreams. The two are broken souls with troubled pasts. Rohit's former girlfriend Raima has been comatose for four years and he blames himself for it. Sonakshi was betrayed by her former boyfriend Karan. Eventually, Rohit and Sonakshi meet but their worlds are poles apart. They bicker and argue, but slowly understand each other's perspective on love and lifestyle and start to see each other in a new light and become friends.
Sonakshi falls in love with Rohit. Unable to move on at first from Raima's memories, Rohit refuses to acknowledge his feelings for Sonakshi but later realises his love for her. Raima finally wakes up from coma. Stubborn and jealous of Rohit and Sonakshi's relationship at first, she later understands their love and leaves. Free from guilt, Rohit marries Sonakshi. He reveals that his father Naren cheated on his mother Veena, by having an extramarital affair with another woman. Pooja who was adopted by Naren's sister Nishi Sippy and her husband Yash Kapoor, treat her like their daughter but in reality, Pooja is Naren's daughter from the extra-marital affair.
Rohit's brother Rohan, whose wife Tanya is pregnant, has an affair with Sonakshi's sister Pari. When this truth comes out, Veena slaps Pari. Pari's mother, Suman, unveils Naren's truth to Veena, shattering her. Naren plans to transfer ownership of his property to Veena and Pooja. Nishi, who is greedy and wants the property at any cost for herself, tries to kill him and blames Sonakshi for the same. But the police officer learns about Sonakshi's innocence through Naren's friend and came to know somebody else in the house had tried to kill Naren. He, with the help of Sonakshi, investigates the case and discovers that Nishi is the culprit. Rohit also uncovered the truth but was blackmailed by Nishi that if he didn't divorce Sonakshi, she will tamper with Naren's health as she has hacked Naren's pacemaker. Helpless, Rohit rudely behaves and ousts Sonakshi from the house, and she meets with an accident. But Rohit saves Sonakshi in time although he does not reveal that it was him who saved her. A broken Sonakshi loses faith in love and tries to move on. On the other side, Rohit starts to destroy himself in thoughts of Sonakshi and his helplessness.
4 months later
Sonakshi and Rohit have separated. She loses her job and is searching for work. Rohit has distanced himself from his family and has become alcoholic. Nishi has taken over the property. Discharged from the hospital, Naren is on a wheelchair. Pari gets pregnant with Rohan's child and plots to get him back to secure her child's future but Sonakshi reprimands her. Tanya miscarries. Rohit gets affected by a virus and in an attempt to save him, Sonakshi finds out the truth that Rohit had been forced to leave her by Nishi who had also caused Naren's accident. She reunites with Rohit and they expose Nishi and her conspiracy, getting her arrested. Veena throws Rohan out for his infidelity. Aakash and Deepa marry, while Rohit and Sonakshi get remarried and everything ends well.
