The show revolves around the life of Dr. Saachi Mishra, a young medical student who aspires to become a successful doctor and joins the prestigious Savitri Devi College & Hospital in pursuit of her dream. Saachi comes from a middle-class family having been brought up by her mother Jaya, who has a secret past with the owner of Savitri Devi Hospital, the famous Dr. Anand Malhotra. Jaya's deceased husband Dr. Sunil Mishra and Anand were business partners. Savitri Devi College and Hospital is built on Sunil's land. The show also features the lives of Dr. Anand Malhotra and his family including his son Dr. Veer and daughter Priya and his second wife Gayatri and her daughter Dr. Riya and Anand's younger brother Adarsh and his wife Neeta. Savitri Devi College & Hospital is named after Anand's deceased wife Savitri who was Jaya's best friend. Later Saachi gets admission as an intern in Savitri Devi College & Hospital with her best friends Dr. Isha Negi and Dr. Pragya Yadav.
Dr. Veer and Dr. Riya are also interns in same hospital. Saachi learns of Mishra family's past with Savitri Devi College and Hospital. Savitri is revealed to be alive and is in same hospital. Anand had hidden Savitri in a room. Saachi finds out that Savitri is alive and guides Veer to that room. Savitri was comatose for fifteen years. Savitri met with an accident 15 years before. Soon Savitri wakes up from coma and returns to Malhotra family. She knows Anand's secret. Veer and Saachi fall in love with each other and get married.
A witch Nayantara haunts the Malhotra family so she can exert revenge on Anand. Years ago a pregnant woman (Nayantara) came to Savitri Devi Hospital for delivery. But she didn't get the care and treatment she needed, so her baby came out stillborn. Nayantara died from the shock and Anand buried Nayantara's body in the same ward. Saachi manages to free Riya whom Nayantara had possessed and saves the family. The serial ends with the Malhotra's turning ward 13 (which was the ward Nayantara died) into "Nayantara pediatric ward" in remembrance of Nayantara and her child.
