The show's plot revolves around the much-adored tale of Parvati (the wife of Shiva) and her alter-ego, Mahakali.
Adishakti, the Goddess of the Universe creates the trinity gods Brahma, Vishnu and Shiva, but creates only two respective wives, one for Brahma and Vishnu, Saraswati and Lakshmi. According to her promise to Shiva, who expressed his love to her, she takes multiple births on earth to woo and wed Him. He is entrusted with the duty of transforming her earthly incarnations into Mahakali but failed 107 times (of which the 107th birth was of Sati). So, Adishakti finally incarnates as the Goddess of the Himalayas and is named as Parvati the 108th birth.
With her strong will and intense devotion, Parvati becomes the wife of Shiva. However, their marriage is threatened when the demon king Shumbha along with his brother Nishumbha and their demon army attacks. Shumbha expresses his desire to marry Parvati and wages war against Shiva. In an attempt to protect all those who have taken up refuge in her home at Mount Kailash, Parvati rushes into the war, successfully channeling Mahakali, her untamed avenger warrior side through her unbound rage. Her rampage inspires other goddesses like Lakshmi, Saraswati and Indrani to bring forth their inner warriors and fight alongside Mahakali.
Mahakali is able to overthrow Shumbha's and Nishumbha's tyrannical rule and slay all his associates (including famed demons like Mahishasura, Bhandasura, Tarakasura, Raktabija and Chanda and Munda) in the process.
In years following her triumph, Shiva and Parvati expand their family to include their sons Ganesha and Kartikeya. Further stories highlight annihilation of threats like Banasura, Narakasura, Arunasura, Durgamasura, Andhakasura and the like – all being formidable demons she famously killed in various incarnations. The show also highlights the importance of family sticking up for each other, as the Kailash-Parivar face multiple social challenges and deconstruct many primitive thought processes.